Alpha 2-adrenoceptor stimulation can augment coronary vasodilation maximally induced by adenosine in dogs.

@article{Hori1989Alpha2S,
  title={Alpha 2-adrenoceptor stimulation can augment coronary vasodilation maximally induced by adenosine in dogs.},
  author={Masatsugu Hori and Masafumi Kitakaze and Jun Tamai and Katsuomi Iwakura and Akira Kitabatake and Michitoshi Inoue and Takenobu Kamada},
  journal={The American journal of physiology},
  year={1989},
  volume={257 1 Pt 2},
  pages={H132-40}
}
To determine whether alpha 2-adrenoceptor stimulation can augment adenosine-induced coronary vasodilation, 34 open-chest dogs were studied. When a small dose of clonidine (up to 0.24 micrograms.kg-1.min-1 ic) was administered under beta-adrenoceptor blockade, coronary blood flow [312 +/- 16 (SE) ml.100 g-1.min-1] maximally induced by intracoronary infusion… CONTINUE READING