Alpha 2-adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats.

@article{Alvarez1993Alpha2B,
  title={Alpha 2-adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats.},
  author={Carlos Alvarez and Cinta Blad{\'e} and J Carta{\~n}{\'a}},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={121 1},
  pages={112-7}
}
To study the involvement of the adrenergic system in nickel-induced hyperglycemia and hepatic glutathione depletion in rats, several adrenergic antagonists (phentolamine, prazosin, yohimbine, and propranolol) were administered in a single ip injection before acute nickel treatment (ip injection). Moreover, the effects of nickel on adrenalectomized rats were investigated. Hyperglycemia was suppressed by either alpha-antagonist phentolamine or alpha 2-antagonist yohimbine. Such blockade coincided… CONTINUE READING