Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task

@article{Arnsten1992Alpha2AA,
  title={Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task},
  author={Amy F. T. Arnsten and Tracy Contant},
  journal={Psychopharmacology},
  year={1992},
  volume={108},
  pages={159-169}
}
With advancing age, monkeys become impaired on a test of spatial working memory, the delayed response task, and show increased susceptibility to interference from irrelevant stimuli (Bartus and Dean 1979). Alpha-2 adrenergic agonists such as clonidine and guanfacine have been shown to improve the delayed response performance of aged monkeys under standard testing conditions (e.g. Arnsten et al. 1988). The current study examined whether these drugs could protect the delayed response performance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Tonotopic organization, architecture and connections of auditory cortex in macaque monkeys

A Morel, PE Garraghty, MK Schwaber, P Burch-Sims, JH Kaas
Soc Neurosci Abstr • 1991
View 1 Excerpt

Lexical priming deficits as a function of age.

Behavioral neuroscience • 1990
View 1 Excerpt

Similar Papers

Loading similar papers…