Alpha 1A-adrenergic receptor polymorphism and vascular response.

  title={Alpha 1A-adrenergic receptor polymorphism and vascular response.},
  author={Gbenga G. Sofowora and Victor Dishy and Ruth Landau and Hong-Guang Xie and Harish Chand Prasad and Daniel W. Byrne and Richard M. Smiley and Richard B Kim and Alastair J. J. Wood and Charles M. Stein},
  journal={Clinical pharmacology and therapeutics},
  volume={75 6},
OBJECTIVE The alpha(1A)-adrenergic receptor is highly expressed in human vasculature including resistance arteries and veins, and its stimulation is primarily responsible for adrenergically mediated smooth muscle contraction. Variability in sensitivity to phenylephrine, an alpha(1A) adrenergic agonist, has a large genetic component. We examined the hypothesis that a common polymorphism of alpha(1A)-adrenergic receptor (Arg347Cys) affects in vivo response. METHODS We measured vascular… CONTINUE READING

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