Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis.

@article{Clemmensen2011Alpha1antitrypsinIP,
  title={Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis.},
  author={Stine Novrup Clemmensen and Lars Christian Jacobsen and Sara R\orvig and Bjarke Askaa and Karin Christenson and Martin Iversen and Marianne H\orby J\orgensen and Maria Torp Larsen and Bo van Deurs and Ole Ostergaard and Niels H. H. Heegaard and Jack Bernard Cowland and Niels Borregaard},
  journal={European journal of haematology},
  year={2011},
  volume={86 6},
  pages={517-30}
}
Alpha-1-antitrypsin (A1AT) is an important inhibitor of neutrophil proteases including elastase, cathepsin G, and proteinase 3. Transcription profiling data suggest that A1AT is expressed by human neutrophil granulocytes during all developmental stages. A1AT has hitherto only been found associated with azurophile granules in neutrophils indicative of A1AT expression being restricted to the promyelocyte stage. We examined the localization and production of A1AT in healthy donor neutrophils and… CONTINUE READING
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