Alpha 1-antitrypsin in human macrophages.

  title={Alpha 1-antitrypsin in human macrophages.},
  author={P B Isaacson and David B. Jones and Mary A. Judd},
  volume={2 8149},
Preliminary studies have suggested that alpha-1-antitrypsin (A1AT) is a useful immunohistochemical marker of histiocytes (monocytes/macrophages) and malignant tumours derived from them. To confirm the reliability of this marker a wide variety of benign and malignant lymphoreticular cells and tissues have been stained by the immunoperoxidase technique for A1AT and positive staining was found to be confined to histiocytes. Immunodiffusion, isotope labelling, and isoelectric focusing studies… CONTINUE READING