Alpha 1-antitrypsin deficiency and liver disease: clinical presentation, diagnosis and treatment.

@article{Hussain1991Alpha1D,
  title={Alpha 1-antitrypsin deficiency and liver disease: clinical presentation, diagnosis and treatment.},
  author={Munther J. Hussain and Giorgina Mieli-Vergani and A. P. Mowat},
  journal={Journal of inherited metabolic disease},
  year={1991},
  volume={14 4},
  pages={497-511}
}
The alpha 1-antitrypsin deficient subject (protease inhibitor (PI) phenotype ZZ) has an increased susceptibility to liver disease. The condition is most commonly identified in early infancy as a conjugated hyperbilirubinaemia with hepatitis (11%) or a bleeding state due to vitamin K malabsorption (2%). 50% of cases have cirrhosis and 25% die in the first decade of life. A further 2% present with cirrhosis in later childhood. Adult males are at risk of hepatoma development with or without… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…