Alpha-1 antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum.

@article{Pandur2009Alpha1AB,
  title={Alpha-1 antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum.},
  author={Edina Pandur and Judit Kolozsv{\'a}rin{\'e} Nagy and Viktor Soma Po{\'o}r and Akos Sarnyai and Andr{\'a}s Husz{\'a}r and Attila Miseta and Katalin Sipos},
  journal={The FEBS journal},
  year={2009},
  volume={276 7},
  pages={2012-21}
}
Recent discoveries have indicated that the hormone hepcidin plays a major role in the control of iron homeostasis. Hepcidin regulates the iron level in the blood through the interaction with ferroportin, an iron exporter molecule, causing its internalization and degradation. As a result, hepcidin increases cellular iron sequestration, and decreases the iron concentration in the plasma. Only mature hepcidin (result of the cleavage of prohepcidin by furin proteases) has biological activity… CONTINUE READING