Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage.

@article{Dardiotis2008Alpha1AG,
  title={Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage.},
  author={Euthimios Dardiotis and Georgios M. Hadjigeorgiou and Maria Dardioti and Nikolaos Scarmeas and Konstantinos Paterakis and Konstantinos Aggelakis and Apostolos Komnos and Anastasia Tasiou and Georgia Xiromerisiou and Ioannis Gabranis and Elias Zintzaras and Alexandros Papadimitriou and Apostolos H Karantanas},
  journal={European neurology},
  year={2008},
  volume={59 6},
  pages={307-14}
}
BACKGROUND/AIMS Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80%) to detect a twofold increase in the odds ratio. METHODS We prospectively… CONTINUE READING