Alpha 1-adrenoceptor desensitisation.


The effects of intravenous infusion with phenylephrine on pressor responses to bolus doses of phenylephrine were examined in conscious rabbits. Four hours infusions failed to attenuate responses except in animals pretreated with phenoxybenzamine to eliminate the alpha 1-adrenoceptor reserve. However, the doses of phenylephrine required to attenuate… (More)


Cite this paper

@article{Hamilton1988Alpha1D, title={Alpha 1-adrenoceptor desensitisation.}, author={C. A. Hamilton and J. Leighton Reid}, journal={European journal of pharmacology}, year={1988}, volume={152 1-2}, pages={179-83} }