Alpha 1-adrenoceptor activation increases ecto-5'-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C.

@article{Kitakaze1995Alpha1A,
  title={Alpha 1-adrenoceptor activation increases ecto-5'-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C.},
  author={Masafumi Kitakaze and Masatsugu Hori and Tomoaki Morioka and Tetsuo Minamino and Seiji Takashima and Yuko Okazaki and Koichi Node and Kazuo Komamura and Katsuomi Iwakura and Takefumi Itoh},
  journal={Circulation},
  year={1995},
  volume={91 8},
  pages={
          2226-34
        }
}
BACKGROUND Adenosine is an important regulator of many cardiac functions and is synthesized primarily by ecto- and cytosolic 5'-nucleotidase. We have previously reported that alpha 1-adrenoceptor blockade attenuates adenosine release from ischemic myocardium, raising the possibility that alpha 1-adrenoceptor activation activates 5'-nucleotidase. This study tested whether activation of protein kinase C by alpha 1-adrenoceptor activation increases 5'-nucleotidase activity and augments adenosine… CONTINUE READING

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