Alpha-1 adrenergic signaling in a cardiac murine atrial myocyte (HL-1) cell line

  title={Alpha-1 adrenergic signaling in a cardiac murine atrial myocyte (HL-1) cell line},
  author={Charlene D. McWhinney and Carl Hansen and Janet D. Robishaw},
  journal={Molecular and Cellular Biochemistry},
Activation of alpha-1 adrenergic receptors in the heart has been shown to result in increased contractile activity, cardiac fetal gene re-expression, and myocyte hypertrophy. Three alpha-1 adrenergic receptors have been identified through molecular cloning. Due to the limited selectivities of the currently available alpha-1 adrenergic receptor antagonists, the signaling pathways activated by specific subtypes in the heart remain unresolved. To resolve this dilemma, we have used a molecular… CONTINUE READING


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Cardiac-specific over expression of alpha1B-AR regulates beta-AR activity via molecular crosstalk

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