Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.

@article{Gil2009Alpha1adrenergicRA,
  title={Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.},
  author={Daniel W Gil and Cynthia V Cheevers and Karen M Kedzie and Cynthia A Manlapaz and Sandhya Rao and Elaine J Y Tang and John E Donello},
  journal={Anesthesiology},
  year={2009},
  volume={110 2},
  pages={401-7}
}
BACKGROUND The use of alpha-2 adrenergic agonists for analgesia is limited due to a narrow therapeutic window. Definition of the role of alpha receptor subtypes in alpha agonist mediated analgesia may identify strategies to separate the analgesic from sedative and cardiovascular effects. METHODS Analgesic activity of brimonidine, clonidine, and tizanidine was investigated in wild-type C57B/6, alpha-2A, and alpha-2C knockout mice with allodynia induced by N-methyl-D-aspartate or sulprostone… CONTINUE READING
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