Alpha 1-adrenergic blockade increases coronary blood flow during coronary hypoperfusion.

@article{Liang1985Alpha1B,
  title={Alpha 1-adrenergic blockade increases coronary blood flow during coronary hypoperfusion.},
  author={I Y Liang and Catherine E Jones},
  journal={The American journal of physiology},
  year={1985},
  volume={249 6 Pt 2},
  pages={H1070-7}
}
Coronary hypoperfusion was elicited in alpha-chloralose-anesthetized open-chest dogs by reducing left coronary perfusion pressure to 50 mmHg. Left coronary blood flow, as well as left ventricular oxygen extraction, oxygen consumption, and contractile force were measured. The reduction in perfusion pressure caused significant reductions in coronary flow, oxygen consumption, and peak reactive hyperemic flow. During hypoperfusion in 11 dogs, intracoronary infusion of the specific alpha 1… CONTINUE READING

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