Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking.

@article{Barthel2009Alpha1F,
  title={Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking.},
  author={Steven R. Barthel and Georg K Wiese and Jaehyung Cho and Matthew J. Opperman and Danielle L. Hays and Javed Ather Siddiqui and Kenneth J. Pienta and Bruce Furie and Charles J. Dimitroff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 46},
  pages={19491-6}
}
How cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, yet essential step in metastasis. We postulate that the metastatic process involves discrete adhesive interactions between circulating cancer cells and microvascular endothelial cells. Sialyl Lewis X (sLe(X)) on prostate cancer (PCa) cells is thought to promote metastasis by mediating PCa cell binding to microvascular endothelial (E)-selectin. Yet, regulation of sLe(X) and related E-selectin… CONTINUE READING