Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.

Abstract

As a part of a program aimed at discovering compounds endowed with alpha(1)-adrenoceptor (AR) blocking properties, in this paper we describe the synthesis and biological characterization of the compounds designed to fully match a three-dimensional pharmacophore model for alpha(1)-AR antagonists previously developed by our research group. Accordingly, the… (More)

Topics

Cite this paper

@article{Betti2002Alpha1adrenoceptorA4, title={Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.}, author={Laura Betti and Maurizio Botta and Federico Corelli and Monia Floridi and Gino Giannaccini and Laura Maccari and Fabrizio Manetti and Giovannella Strappaghetti and Andrea Tafi and Stefano Corsano}, journal={Journal of medicinal chemistry}, year={2002}, volume={45 17}, pages={3603-11} }