Alpha‐adrenergic blockers: Mechanism of action, blood pressure control, and effects on lipoprotein metabolism

@article{Nash1990AlphaadrenergicBM,
  title={Alpha‐adrenergic blockers: Mechanism of action, blood pressure control, and effects on lipoprotein metabolism},
  author={David T. Nash},
  journal={Clinical Cardiology},
  year={1990},
  volume={13}
}
  • D. Nash
  • Published 1 November 1990
  • Medicine
  • Clinical Cardiology
The sympathetic nervous system plays a major role in the pathogenesis of essential hypertension and is mediated by the α and β receptors. The α receptor is divided into two types, α1 and α2 based on response to epinephrine and norepinephrine. α1‐Adrenergic receptors have a high affinity for drugs such as prazosin, doxazosin, and terazosin, which act to reduce blood pressure by selective blockade of the receptor. These agents provide a rational approach to the treatment of hypertension by… Expand
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