Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism.

@article{Tesfay2008AlphabetaII,
  title={Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism.},
  author={Mulu Z Tesfay and Jun Yin and Christina L. Gardner and Mikhail V. Khoretonenko and Nadejda L Korneeva and R. E. Rhoads and Kate D. Ryman and William B Klimstra},
  journal={Journal of virology},
  year={2008},
  volume={82 6},
  pages={2620-30}
}
The alpha/beta interferon (IFN-alpha/beta) response is critical for host protection against disseminated replication of many viruses, primarily due to the transcriptional upregulation of genes encoding antiviral proteins. Previously, we determined that infection of mice with Sindbis virus (SB) could be converted from asymptomatic to rapidly fatal by elimination of this response (K. D. Ryman et al., J. Virol. 74:3366-3378, 2000). Probing of the specific antiviral proteins important for IFN… CONTINUE READING

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