Alpha,beta-D-CNA induced rigidity within oligonucleotides.

  title={Alpha,beta-D-CNA induced rigidity within oligonucleotides.},
  author={Christelle Dupouy and Nathalie Ich{\'e}-Tarrat and Marie-Pierre Durrieu and Alain Vigroux and Jean-Marc Escudier},
  journal={Organic & biomolecular chemistry},
  volume={6 16},
Introduction of alpha,beta-D-CNA featuring canonical values of the torsional angles alpha and beta within oligonucleotides leads to an overall stabilization and improved rigidity of the duplex DNA as demonstrated by UV experiments, circular dichroism and corroborated by molecular dynamics simulations.