Alpha(1)-adrenergic-mediated eNOS phosphorylation in intact arteries.

  title={Alpha(1)-adrenergic-mediated eNOS phosphorylation in intact arteries.},
  author={Robin C Looft-Wilson and Sarah E. Todd and Christina A. Araj and Stephanie Mutchler and Cara A Raphael Goodell},
  journal={Vascular pharmacology},
  volume={58 1-2},
Activation of arterial smooth muscle alpha(1)-adrenergic receptors results in vasoconstriction, as well as a secondary release of nitric oxide and slow vasodilation, presumably through gap junction communication from smooth muscle to endothelium. We hypothesized that this slow vasodilation is due to activation of eNOS through phosphorylation at Ser1179 and dephosphorylation at Thr495. Phosphorylation was measured by western blot using mouse mesenteric arteries that were cannulated and… CONTINUE READING


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