Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers.

@article{Houghton2000AlosetronA5,
  title={Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers.},
  author={L A Houghton and Jessica M Foster and Peter J Whorwell},
  journal={Alimentary pharmacology & therapeutics},
  year={2000},
  volume={14 6},
  pages={775-82}
}
BACKGROUND Alosetron is a potent and selective 5-HT3 receptor antagonist, which has been shown to be beneficial in the treatment of female patients with non-constipated irritable bowel syndrome. AIMS To investigate the effect of alosetron on whole gut, small bowel and colonic transit in patients with irritable bowel syndrome (Study 1) and healthy… CONTINUE READING