Alopecia Areata: An Evidence-Based Treatment Update

  title={Alopecia Areata: An Evidence-Based Treatment Update},
  author={Maria K. Hordinsky and Aline Donati},
  journal={American Journal of Clinical Dermatology},
BackgroundThere is no cure for alopecia areata, nor is there any universally proven therapy that induces and sustains remission. Treatment choices are frequently based on disease duration, extent, and activity as well as the age of the patient.ObjectiveOur objective was to review all randomized controlled studies on the treatment of alopecia areata.MethodsWe performed a search in the biomedical literature database PubMed, and used the terms ‘alopecia areata treatment’ and article type… 

Current Treatments for Alopecia Areata.

  • M. Hordinsky
  • Medicine
    The journal of investigative dermatology. Symposium proceedings
  • 2015
Before selecting a treatment for patients with extensive long-standing AA, a scalp biopsy may provide useful information about the degree of inflammation and follicle differentiation.

Emerging drugs for alopecia areata: JAK inhibitors

It is hoped that JAK inhibitors will become part of the armamentarium to treat alopecia areata patients in terms of safety and costs, but further studies are needed on long term safety.

New Modalities in the Treatment of Refractory Alopecia Areata

The current treat ment options in recalcitrant alopecia areata are reviewed based on recently published studies and then the recently developed broad-spectrum and targeted therapeutics are focused on.

Off-Label Use of Topical Minoxidil in Alopecia: A Review

A comprehensive review of the literature indicates that while minoxidil is routinely used in the management of many alopecic conditions, there is mixed evidence for its efficacy and for certain conditions, the evidence seems to be inconclusive.

Alopecia areata update.

In this manuscript, the clinical presentation, epidemiology, pathophysiology, plus current and evolving treatments for AA will be reviewed.

Italian guidelines in diagnosis and treatment of alopecia areata.

  • A. RossiM. Muscianese M. C. Fortuna
  • Medicine, Biology
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
  • 2019
Evidence-based treatment associated with expert-based recommendations is summarized, deeming useful for the daily management of the disease Alopecia Areata.

Alopecia Areata: The Clinical Situation.

  • M. Hordinsky
  • Medicine, Psychology
    The journal of investigative dermatology. Symposium proceedings
  • 2018

Systemic Therapies for Scarring and Non-scarring Alopecia

TreatingPrimary scarring (cicatricial) and non-scarring alopecias comprise a diverse group of diseases that range from very common to very rare, making it difficult to determine whether or not a particular treatment will be consistently effective for different patients.

Understanding autoimmunity of vitiligo and alopecia areata

The identification of IFN&ggr;-driven immune signaling pathways has enabled discoveries of potential new treatments for vitiligo and alopecia areata, and supports initiation of larger clinical trials.



Topical minoxidil lacks efficacy in alopecia areata.

To the Editor.— Since the original report by Weiss et al 1 there have been several enthusiastic reports on the efficacy of topical minoxidil in the treatment of alopecia areata. 2-4 This trend was

Inosiplex for treatment of alopecia areata: a randomized placebo-controlled study.

Larger studies are required, however, before inosiplex may be recommended as an efficacious and safe alternative systemic form of therapy for recalcitrant alopecia areata with insignificant side-effects, compared with placebo.

Subcutaneous efalizumab is not effective in the treatment of alopecia areata.

Alopecia Areata following Adalimumab

A case of alopecia areata is reported that developed in a 52-year-old woman who was recently started on adalimumab for treatment of her psoriatic arthritis, the first report of a new-onset alop Cecilia areata following ad alimumab.

Management of alopecia areata

The most effective treatment in severe alopecia is contact immunotherapy, however, the long-term response rate in this group of patients is low, it is available in only a few centres and there are significant safety considerations for patients and carers.

Pulse Corticosteroid Therapy for Alopecia Areata: Study of 139 Patients

Evaluated pulse corticosteroid therapy for recent-onset alopecia areata patients with a history of ≤1 year found it to be effective for patients with less severe disease, but only 21.4% of recent-ONSet patients with 100% hair loss responded.

Placebo-controlled oral pulse prednisolone therapy in alopecia areata.

Randomized trial of aromatherapy. Successful treatment for alopecia areata.

Treatment with these essential oils was significantly more effective than treatment with the carrier oil alone (P = .008 for the primary outcome measure) and an evidence-based method was successfully applied to an alternative therapy.

Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata

The present pilot study showed that the use of azelaic acid gave similar results to anthralin with regard to hair regrowth, and that it can be an effective topical therapy for patchy AA.