SHOWING 1-7 OF 7 REFERENCES
Adjuvant clinical effects of polydeoxyribonucleotide in lichen sclerosus.
- MedicineEuropean journal of dermatology : EJD
All patients had a history of unresponsiveness or slight improvement to potent topical steroid (clobetasol 17-propionate 0.05%) and were evaluated in compliance with the recent guidelines of the British Association of Dermatologists.
Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A(₂A) receptor.
- Medicine, BiologyArthritis and rheumatism
PDRN treatment significantly ameliorated clinical signs of arthritis, improved histologic damage, reduced the cartilage expression and circulating levels of HMGB-1, TNFα, and IL-6, and enhanced IL-10 expression, and reduced cytokine production from stimulated human chondrocytes.
In vitro polydeoxyribonucleotide effects on human pre‐adipocytes
- BiologyCell proliferation
The data suggest that PDRN could act as a pre‐adipocyte growth stimulator, and purine nucleosides and nucleotides mixtures can act as mitogens for several cell types.
Effect of polydeoxyribonucleotides on human fibroblasts in primary culture.
- BiologyCell biochemistry and function
Results are interpreted assuming that PDRN and the nucleotides and nucleosides resulting from its degradation, can act as signal transducers or, alternatively, can be internalized and utilized to provide purine and pyrimidine rings for the salvage pathways.
Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus: Adjuvant Effects during Topical Therapy
- Medicine, BiologyDermatology research and practice
On site intradermal administration of PDRN, associated with CP 0.05% cream, seemed to be associated with a clinical improvement of lichen sclerosus better than CP used in single therapy.
- Coradeghini et al., “In vitro polydeoxyribonucleotide effects on human pre-adipocytes,” Cell Proliferation, vol. 41, no. 5, pp. 739– 754,
- Irrera et al., “Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A2A receptor,” Arthritis and Rheumatism, vol. 63, no. 11, pp. 3364–3371,