Alogliptin Use in Elderly People: A Pooled Analysis from Phase 2 and 3 Studies

@article{Pratley2009AlogliptinUI,
  title={Alogliptin Use in Elderly People: A Pooled Analysis from Phase 2 and 3 Studies},
  author={Richard E. Pratley and Th{\'e}r{\`e}se McCall and Penny Fleck and Craig A. Wilson and QaisA. Mekki},
  journal={Journal of the American Geriatrics Society},
  year={2009},
  volume={57}
}
OBJECTIVES: To compare the efficacy and safety of alogliptin, a dipeptidyl peptidase‐4 (DPP‐4) enzyme inhibitor, in elderly (≥65) and younger (<65) patients with type 2 diabetes mellitus. 
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Background Citations
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TLDR
Patients with type 2 diabetes who achieved inadequate glycaemic control on pioglitazone plus diet/exercise are studied to assess the efficacy and safety of alogliptin added to piog Litazone versus piog litazone monotherapy.
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TLDR
The aim of this study is the assessment of predictors of response to DPP‐4 inhibitors.
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Clinical trial data with alogliptin demonstrate clinical efficacy in terms of A1C and FPG reductions when used both as monotherapy and in combination with other oral antidiabetic medications.
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