Corpus ID: 18099164

Almitrine in low dose potentiates vasoconstrictor responses of isolated rat lungs to moderate hypoxia.

@article{Falus1991AlmitrineIL,
  title={Almitrine in low dose potentiates vasoconstrictor responses of isolated rat lungs to moderate hypoxia.},
  author={F. Falus and Jan Herget and V{\'a}clav Hampl},
  journal={The European respiratory journal},
  year={1991},
  volume={4 6},
  pages={
          688-93
        }
}
  • F. Falus, Jan Herget, Václav Hampl
  • Published in
    The European respiratory…
    1991
  • Medicine
  • To test whether the effect of almitrine on hypoxic pulmonary vasoconstriction was dose-dependent, two series of experiments were performed on isolated rat lungs perfused with constant flow of blood. In the first series, the effects of different doses of almitrine on perfusion pressure were measured. Baseline perfusion pressure was not changed by solvent or by 0.25 micrograms.ml-1 almitrine, but it was increased by 0.5 and 2.0 micrograms.ml-1 almitrine. The increase in perfusion pressure in… CONTINUE READING

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