Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways.

@article{De2017AllylpyrocatecholAC,
  title={Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways.},
  author={Soumita De and Alak Manna and Sunanda Kundu and Sritama De Sarkar and Uttara Chatterjee and Tuhinadri Sen and Subrata Kumar Chattopadhyay and Mitali Chatterjee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2017},
  volume={360 2},
  pages={
          249-259
        }
}
Rheumatoid arthritis (RA), an inflammatory autoimmune disorder, is characterized by synovial hyperplasia and bony destruction. The pathogenesis of RA includes redox dysregulation, concomitant with increased levels of proinflammatory mediators. As the ability of allylpyrocatechol (APC), a phytoconstituent of Piper betle leaves, to alleviate oxidative stress has been demonstrated in patients with RA, its antiarthritic activity was evaluated in an animal model of arthritis, and the underlying… CONTINUE READING

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