Allylic oxidation of steroidal olefins by vanadyl acetylacetonate and tert-butyl hydroperoxide.


Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetylacetonate in one pot reactions at room… (More)
DOI: 10.1016/j.steroids.2015.06.005

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