Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29.

@article{Musk1993AllylII,
  title={Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29.},
  author={S. R. R. Musk and Ian T Johnson},
  journal={Carcinogenesis},
  year={1993},
  volume={14 10},
  pages={
          2079-83
        }
}
Allyl isothiocyanate, a constituent of mustard and certain vegetables found in the human diet, was tested for cytotoxic and cytostatic effects in HT29 human colon carcinoma cells in vitro. For an exposure time of 24 h, allyl isothiocyanate exhibited a Dq of 0.32 microgram/ml and a D0 of 0.74 micrograms/ml. Following detransformation of the cells by treatment with sodium butyrate or dimethylformamide the cells became more resistant to the cytotoxic effects of allyl isothiocyanate, the Dq… CONTINUE READING

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