Allyl isothiocyanate: comparative disposition in rats and mice.

  title={Allyl isothiocyanate: comparative disposition in rats and mice.},
  author={Y M Ioannou and Leo T. Burka and Hilary Matthews},
  journal={Toxicology and applied pharmacology},
  volume={75 2},
Allyl isothiocyanate (AITC), the major component of volatile oil of mustard, was recently reported to induce transitional-cell papillomas in the urinary bladder of male Fischer 344 rats, but not in the bladders of female rats or B6C3F1 mice. The present investigation of comparative disposition in both sexes of each species was designed to detect sex or species differences in disposition which might explain susceptibility to AITC toxicity. AITC was readily cleared from all rat and mouse tissues… CONTINUE READING
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