Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.

@article{Maddox2003AllylAA,
  title={Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.},
  author={Jillian F. Maddox and Robert A. Roth and Patricia E. Ganey},
  journal={Chemical research in toxicology},
  year={2003},
  volume={16 5},
  pages={
          609-15
        }
}
Hepatotoxicity of allyl alcohol involves its bioactivation to acrolein and subsequent protein sulfhydryl loss and lipid peroxidation. However, the links between these events and hepatocellular death are not known. The purpose of these studies was to examine whether specific signal transduction pathways are associated with allyl alcohol toxicity in hepatocytes. Inhibition or augmentation of cyclic AMP and/or protein kinase A (PKA) by Rp-Ado-3N,5N-cyclic monophosphorothioate triethylamine salt or… CONTINUE READING

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