- Published 2015 in IEEE Trans. Med. Imaging

Material basis decomposition in the sinogram domain requires accurate knowledge of the forward model in spectral computed tomography (CT). Misspecifications over a certain limit will result in biased estimates and make quantum limited (where statistical noise dominates) quantitative CT difficult. We present a method whereby users can determine the degree of allowed misspecification error in a spectral CT forward model and still have quantification errors that are limited by the inherent statistical uncertainty. For a particular silicon detector based spectral CT system, we conclude that threshold determination is the most critical factor and that the bin edges need to be known to within 0.15 keV in order to be able to perform quantum limited material basis decomposition. The method as such is general to all multibin systems.

@article{Bornefalk2015AllowableFM,
title={Allowable Forward Model Misspecification for Accurate Basis Decomposition in a Silicon Detector Based Spectral CT},
author={Hans Bornefalk and Mats Persson and Mats Danielsson},
journal={IEEE transactions on medical imaging},
year={2015},
volume={34 3},
pages={788-95}
}