Allotype-associated variation in the human gamma3 switch region as a basis for differences in IgG3 production.

@article{Pan1997AllotypeassociatedVI,
  title={Allotype-associated variation in the human gamma3 switch region as a basis for differences in IgG3 production.},
  author={Qiang Pan and Hodjattallah Rabbani and Frederick C. Mills and Eva Severinson and Lennart Hammarstr{\"o}m},
  journal={Journal of immunology},
  year={1997},
  volume={158 12},
  pages={5849-59}
}
High and low serum concentrations of IgG3 are associated with the human G3 m(b) and G3 m(g) allotypes, respectively. We previously hypothesized that a low frequency of switching is the most likely defect in (g) allotype-positive individuals, and therefore analyzed the structure, recombination breakpoints, and binding of nuclear proteins to the switch (S)gamma3 regions of these two allotypes. There are no allotype-associated differences in the length and basic structure of the Sgamma3, since… CONTINUE READING

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