Allosuppressor and allohelper T cells in acute and chronic graft-vs.- host disease. II. F1 recipients carrying mutations at H-2K and/or I-A

Abstract

By induction of a graft-vs.-host reaction (GVHR) in nonirradiated H-2-different F1 mice, one can induce stimulatory pathological symptoms, such as lymphadenopathy and hypergammaglobulinemia, combined with the production of autoantibodies characteristic of systemic lupus erythematosus (SLE). Alternatively, the GVHR can lead to the suppressive pathological… (More)

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