Allostery without conformational change. A plausible model.

@article{Cooper1984AllosteryWC,
  title={Allostery without conformational change. A plausible model.},
  author={Alan H Cooper and David T. F. Dryden},
  journal={European biophysics journal : EBJ},
  year={1984},
  volume={11 2},
  pages={103-9}
}
A general model is presented whereby ligand-induced changes in protein dynamics could produce allosteric communication between distinct binding sites, even in the absence of a macromolecular conformational change. Theoretical analysis, based on the statistical thermodynamics of ligand binding, shows that cooperative interaction free energies amounting to several kJ . mol-1 may be generated by this means. The effect arises out of the possible changes in frequencies and amplitudes of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 136 extracted citations

Similar Papers

Loading similar papers…