Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution.

Abstract

DegS is a periplasmic Escherichia coli protease, which functions as a trimer to catalyze the initial rate-limiting step in a proteolytic cascade that ultimately activates transcription of stress response genes in the cytoplasm. Each DegS subunit consists of a protease domain and a PDZ domain. During protein folding stress, DegS is allosterically activated… (More)
DOI: 10.1074/jbc.M110.135541

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