Allostery in the lac operon: population selection or induced dissociation?

@article{Sharp2011AllosteryIT,
  title={Allostery in the lac operon: population selection or induced dissociation?},
  author={Kim A. Sharp},
  journal={Biophysical chemistry},
  year={2011},
  volume={159 1},
  pages={66-72}
}
Allostery, the modulation of function of a protein at one site by the binding of a ligand at a different site, is a property of many proteins. Two kinetically distinct models have been proposed: i) The induced fit model in which the ligand binds to the protein and then induces the conformational change. ii) The population selection model, in which the protein spontaneously undergoes a conformational change, which is then 'captured' by the ligand. Using measured kinetic constants for the lac… CONTINUE READING

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