Allostery in Caspases

  title={Allostery in Caspases},
  author={Debajyoti Datta},
Author(s): Datta, Debajyoti | Advisor(s): Wells, James A | Abstract: Caspases are a family of dimeric thiol proteases central to the inflammatory and apoptotic pathways. Structural studies of the major inflammatory caspase, caspase-1, reveal that the enzyme exists in two states: an on-state when the active site is occupied; or an off-state when the active site is empty or when the enzyme is bound by allosteric ligand at the dimer interface. Determining which residues and regions of the enzyme… CONTINUE READING