Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution*

  title={Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution*},
  author={Jessica M. Richard and Elizabeth D. Kim and Hoang Nguyen and Catherine D. Kim and Sunyoung Kim},
  journal={The Journal of Biological Chemistry},
  pages={20932 - 20945}
How signals between the kinesin active and cytoskeletal binding sites are transmitted is an open question and an allosteric question. By extracting correlated evolutionary changes within 700+ sequences, we built a model of residues that are energetically coupled and that define molecular routes for signal transmission. Typically, these coupled residues are located at multiple distal sites and thus are predicted to form a complex, non-linear network that wires together different functional sites… 

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