Allosteric targeting of receptor tyrosine kinases

@article{Smet2014AllostericTO,
  title={Allosteric targeting of receptor tyrosine kinases},
  author={Frederik De Smet and Arthur Christopoulos and Peter Carmeliet},
  journal={Nature Biotechnology},
  year={2014},
  volume={32},
  pages={1113-1120}
}
The drug discovery landscape has been transformed over the past decade by the discovery of allosteric modulators of all major mammalian receptor superfamilies. Allosteric ligands are a rich potential source of drugs and drug targets with clear therapeutic advantages. G protein–coupled receptors, ligand-gated ion channels and intracellular nuclear hormone receptors have all been targeted by allosteric modulators. More recently, a receptor tyrosine kinase (RTK) has been targeted by an… 
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