Allosteric signaling of ATP hydrolysis in GroEL–GroES complexes

@article{Ranson2006AllostericSO,
  title={Allosteric signaling of ATP hydrolysis in GroEL–GroES complexes},
  author={Neil A. Ranson and Daniel Kofi Clare and George William Farr and David Houldershaw and Arthur L Horwich and Helen R Saibil},
  journal={Nature Structural &Molecular Biology},
  year={2006},
  volume={13},
  pages={147-152}
}
The double-ring chaperonin GroEL and its lid-like cochaperonin GroES form asymmetric complexes that, in the ATP-bound state, mediate productive folding in a hydrophilic, GroES-encapsulated chamber, the so-called cis cavity. Upon ATP hydrolysis within the cis ring, the asymmetric complex becomes able to accept non-native polypeptides and ATP in the open, trans ring. Here we have examined the structural basis for this allosteric switch in activity by cryo-EM and single-particle image processing… CONTINUE READING
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