Allosteric regulation of Argonaute proteins by miRNAs

  title={Allosteric regulation of Argonaute proteins by miRNAs},
  author={Sergej Djuranovic and Michelle Kim Zinchenko and Junho K Hur and Ali Nahvi and Julie L. Brunelle and Elizabeth J. Rogers and Rachel Green},
  journal={Nature Structural &Molecular Biology},
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of allosterically regulated bacterial ligand-binding domains. We used in vitro and in vivo approaches to show that certain AGO proteins (those… CONTINUE READING


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Argonaute protein as a linker to command center of physiological processes.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu • 2013
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