Allosteric regulation of Argonaute proteins by miRNAs

@article{Djuranovic2010AllostericRO,
  title={Allosteric regulation of Argonaute proteins by miRNAs},
  author={Sergej Djuranovic and Michelle Kim Zinchenko and Junho K Hur and Ali Nahvi and Julie L. Brunelle and Elizabeth J. Rogers and Rachel Green},
  journal={Nature Structural &Molecular Biology},
  year={2010},
  volume={17},
  pages={144-150}
}
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of allosterically regulated bacterial ligand-binding domains. We used in vitro and in vivo approaches to show that certain AGO proteins (those… CONTINUE READING

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