Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors.

@article{Hedlund1999AllostericRB,
  title={Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors.},
  author={Peter B. Hedlund and Monica J. Carson and J. Gregor Sutcliffe and E. A. Thomas},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 11},
  pages={1807-13}
}
Oleamide belongs to a family of amidated lipids with diverse biological activities, including sleep induction and signaling modulation of several 5-hydroxytryptamine (5-HT) receptor subtypes, including 5-HT1A, 5-HT2A/2C, and 5-HT7. The 5-HT7 receptor, predominantly localized in the hypothalamus, hippocampus, and frontal cortex, stimulates cyclic AMP formation and is thought to be involved in the regulation of sleep-wake cycles. Recently, it was proposed that oleamide acts at an allosteric site… CONTINUE READING

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