Allosteric proteins and cellular control systems.

@article{Monod1963AllostericPA,
  title={Allosteric proteins and cellular control systems.},
  author={Jacques Louis Monod and Jean Pierre Changeux and François Jacob},
  journal={Journal of molecular biology},
  year={1963},
  volume={6},
  pages={
          306-29
        }
}
The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions. The effect of these regulatory agents appears to result exclusively from a conformational alteration (allosteric transition) induced in the protein when it binds the agent. It is suggested that this mechanism plays an essential role in the regulation of metabolic activity and also possibly in the specific control of protein synthesis. 
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