Allosteric properties of the 5-HT2 receptor system of the rat tail artery

@article{Frenken1987AllostericPO,
  title={Allosteric properties of the 5-HT2 receptor system of the rat tail artery},
  author={Michael Frenken and Alberto Julio Kaumann},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1987},
  volume={335},
  pages={359-366}
}
We present an analysis of the interactions of 5-hydroxytryptamine (5-HT) and antagonists (methysergide, ketanserin, ritanserin) with the 5-HT2 receptor system of strips of rat tail artery. The mode of action of ritanserin was also studied on strips of calf coronary arteries. 1. Ketanserin competitively antagonized 5-HT-induced effects in rat tail artery with an affinity (pKB = 9.4 nmol/l) consistent with the assumption of an interaction of 5-HT and ketanserin at 5-HT2-receptors. 2. Methysergide… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 11 references

Rule of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle

  • ML Cohen, KW Schenk, W Colbert, L Wittensuer
  • J Pbarmacol Exp Ther
  • 1985
1 Excerpt

Are vascular 'D' and '5-HT2' receptors for 5-hydroxytryptamine the same

  • PB Bradley, PPA Humphrey, RH Williams
  • Br J Pharmacol
  • 1983
2 Excerpts

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