Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.

  title={Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.},
  author={Karen Stanger and Micah Steffek and Lijuan Zhou and Christine D Pozniak and Clifford L Quan and Yvonne Franke and Jeff Y.K. Tom and Christine L Tam and Irina Krylova and James Michael Elliott and Joseph W Lewcock and Yingnan Zhang and Jeremy Murray and Rami N. Hannoush},
  journal={Nature chemical biology},
  volume={8 7},
The caspases are a family of cytosolic proteases with essential roles in inflammation and apoptosis. Drug discovery efforts have focused on developing molecules directed against the active sites of caspases, but this approach has proved challenging and has not yielded any approved therapeutics. Here we describe a new strategy for generating inhibitors of caspase-6, a potential therapeutic target in neurodegenerative disorders, by screening against its zymogen form. Using phage display to… CONTINUE READING
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