Allosteric modulators of NMDA receptors: multiple sites and mechanisms.

  title={Allosteric modulators of NMDA receptors: multiple sites and mechanisms.},
  author={Shujia Zhu and Pierre Paoletti},
  journal={Current opinion in pharmacology},
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that are essential mediators of excitatory neurotransmission and synaptic plasticity. NMDARs are also implicated in a plethora of neuropathological conditions thus receiving strong interest as potential therapeutic targets. Recent years have witnessed major progress in our understanding of the structure and pharmacology of NMDARs with the decoding of the first full-length receptor crystal structures and the discovery of… CONTINUE READING
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