Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.

  title={Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.},
  author={Karen J. Gregory and Elizabeth N Dong and Jens Meiler and P Jeffrey Conn},
  volume={60 1},
Allosteric modulation of G protein-coupled receptors (GPCRs) represents a novel approach to the development of probes and therapeutics that is expected to enable subtype-specific regulation of central nervous system target receptors. The metabotropic glutamate receptors (mGlus) are class C GPCRs that play important neuromodulatory roles throughout the brain, as such they are attractive targets for therapeutic intervention for a number of psychiatric and neurological disorders including anxiety… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 40 extracted citations

Novel Allosteric Modulators of G Protein-coupled Receptors.

The Journal of biological chemistry • 2015
View 6 Excerpts
Highly Influenced

Mavoglurant as a treatment for Parkinson's disease.

Expert opinion on investigational drugs • 2014
View 20 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 236 references

Fragile X: Translation in Action

Neuropsychopharmacology • 2008
View 9 Excerpts
Highly Influenced

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

Nature Reviews Drug Discovery • 2005
View 4 Excerpts
Highly Influenced

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Proceedings of the National Academy of Sciences of the United States of America • 2013

Similar Papers

Loading similar papers…