Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.

@article{Gregory2011AllostericMO,
  title={Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.},
  author={Karen J. Gregory and Elizabeth N Dong and Jens Meiler and P Jeffrey Conn},
  journal={Neuropharmacology},
  year={2011},
  volume={60 1},
  pages={66-81}
}
Allosteric modulation of G protein-coupled receptors (GPCRs) represents a novel approach to the development of probes and therapeutics that is expected to enable subtype-specific regulation of central nervous system target receptors. The metabotropic glutamate receptors (mGlus) are class C GPCRs that play important neuromodulatory roles throughout the brain, as such they are attractive targets for therapeutic intervention for a number of psychiatric and neurological disorders including anxiety… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 236 references

Fragile X: Translation in Action

Neuropsychopharmacology • 2008
View 9 Excerpts
Highly Influenced

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

Nature Reviews Drug Discovery • 2005
View 4 Excerpts
Highly Influenced

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Proceedings of the National Academy of Sciences of the United States of America • 2013

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