Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster.

@article{Hosie1996AllostericMO,
  title={Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster.},
  author={Alastair M. Hosie and David B Sattelle},
  journal={British journal of pharmacology},
  year={1996},
  volume={117 6},
  pages={1229-37}
}
1. Functional GABA-gated chloride channels are formed when cRNA encoding the Drosophila melanogaster GABA receptor subunit RDL is injected into the cytoplasm of Xenopus oocytes. Two-electrode voltage-clamp was used to investigate allosteric modulation of GABA-induced currents recorded from the expressed, bicuculline-insensitive, RDL homo-oligomers. 2. Flunitrazepam (0.1 microM to 100 microM) had no effect on the amplitude of responses to 10 microM GABA (approximately EC10), whereas 4… CONTINUE READING

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