Allosteric modulation of A(2A) adenosine receptors by amiloride analogues and sodium ions.

@article{Gao2000AllostericMO,
  title={Allosteric modulation of A(2A) adenosine receptors by amiloride analogues and sodium ions.},
  author={Zhi Gao and Adriaan P. IJzerman},
  journal={Biochemical pharmacology},
  year={2000},
  volume={60 5},
  pages={669-76}
}
Allosteric regulation of rat A(2A) adenosine receptors by amiloride, amiloride analogues, and sodium ions was studied by investigating their ability to influence the dissociation of [(3)H]4-2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3, 5]triazin-5-yl-amino]ethylphenol ([(3)H]ZM241385) from receptors in rat striatal membranes. Both amiloride and its analogues accelerated the dissociation, the analogues being more potent than amiloride itself. In contrast, sodium ions decreased the rate of… CONTINUE READING

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