Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain

@article{Bagdas2018AllostericMO,
  title={Allosteric modulation of $\alpha$4$\beta$2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain},
  author={Deniz Bagdas and Donmez Merve Ergun and Asti B. Jackson and Wisam Toma and Marvin K. Schulte and Mohamad Imad Damaj},
  journal={European Journal of Pain},
  year={2018},
  volume={22}
}
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels. The α4β2 subtype of nAChRs plays an important role in the mediation of pain and several nicotine‐evoked responses. Agonists and partial agonists of α4β2 nAChRs show efficacy in animal pain models. In addition, the antinociceptive properties of nicotine, a non‐selective nAChR agonist with a high affinity for α4β2 nAChRs, is well‐known. There is a growing body of evidence pointing to allosteric modulation of nAChRs… 

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TLDR
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TLDR
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TLDR
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